Biochemistry
June 1, 2020
Olga J. Baker
Sep. 15, 2019
Michael Baldwin
Baldwin’s laboratory is focused on understanding how bacterial pathogens cause disease in the human population. In particular, he is studying botulinum neurotoxins, soluble proteins that readily diffuse from the site of infection to alter neuronal cell function with damaging effects on the intoxicated individual. The central theme of his research is to understand the molecular basis of protein translocation, the process by which the toxin catalytic domain is transported across the endosomal membrane bilayer to the cell cytosol. To pursue this goal, he has developed new spectroscopic and biochemical approaches to study the insertion of toxin into the membrane, which…
Sep. 7, 2019
Lloyd W. Sumner
The research focus of the Sumner lab includes the development of cutting-edge technologies for large-scale biochemical profiling of plant metabolites (i.e. metabolomics) and integrating these with other omics data. These technologies are then applied in a symbiotic manner for plant gene discovery, gene characterization and the elucidation of mechanistic responses to external stimuli; especially related to plant specialized metabolism or plant natural products biosynthesis. Technology enables the biology and the biology drives technology development. Current technology development projects include the development of a sophisticated and integrated ensemble including UHPLC-MS-SPE-NMR for the systematic and biologically driven annotation of plant metabolomes. This…
Sep. 7, 2019
Jay J. Thelen
Educational background Ph.D. Biological Sciences, University of Missouri Courses taught Biochemistry 4272/7272: Biochemistry…
Sep. 7, 2019
Scott C. Peck
Educational background Ph.D., Michigan State University Courses taught Biochemistry 2480: Introduction to Macromolecular Structure and Function Biochemistry 8200: Principles and Research Practices in Biochemistry…
Sep. 7, 2019
Lesa J. Beamer
Educational background Ph.D., Johns Hopkins University School of Medicine Courses taught Problem-Based Learning (PBL) for 1st and 2nd year medical students Graduate Level Structural Biology for the Life Sciences…
Sep. 7, 2019
Steven R. Van Doren
Dynamic biological assemblies are strategic and fascinating. We have been exploring molecular recognition by flexible proteins and automatic tracking of changes in complex spectra and medical images. Molecular recognition by proteins with intrinsic disorder A pivotal virus-membrane interaction: Coronaviruses use a region of Spike to merge the viral envelope with the host cell membrane. We continue to be interested in the nature of the lipid interactions with this fusogenic region of Spike. Our articles reported (i) the NMR structure of the fusion peptide in a simple membrane-mimicking environment and (ii) its insertion and distortion of the simple membrane mimic via…
Sep. 7, 2019
Gerald Hazelbauer, PhD
Education BS Biology Williams College Williamstown, Mass. MS Biology Case Western Reserve University Cleveland, Ohio PhD Genetics University of Wisconsin Madison, Wis. Research Area Transmembrane receptors and sensory transduction in bacterial chemotaxis. Research Description The aim of our research is to elucidate molecular mechanisms of transmembrane receptors and sensory transduction. For more than 40 years our research group has provided important information about the transmembrane chemoreceptors and signaling complexes that mediate chemotaxis in Escherichia coli. We have helped make bacterial chemotaxis the best understood signaling system in biology and a favored subject for systems biology. Our experimental approaches combine biochemistry,…
Sep. 6, 2019
John J. Tanner
Educational background Ph.D. Chemistry, Brown University, 1988…
Sep. 6, 2019
Michael S. Chapman
Structural Virology – Host Interactions: The US Food & Drug Administration has now approved two gene replacement therapies: Luxturna™ (2017), a treatment for congenital blindness and Zolgenesma™ (2019) for spinal muscular atrophy (SMA). 1,500 SMA infants have now been treated for this debilitating and fatal genetic disorder. These, and treatments for hemophilia and other diseases, use recombinant rAAV vectors to deliver DNA to afflicted cells. Our structure-function analyses provide a fundamental understanding of the atomic interactions key to cell entry, trafficking, and immune neutralization. These foundations are needed for the engineering of gene therapy vectors that are efficient and specific enough…