Research Summary

Our laboratory uses structural biology and other biophysical methods to characterize enzyme function. A primary technique employed by the laboratory is X-ray crystallography, which provides atomic resolution information on the three-dimensional structures of macromolecules. Our overall focus is characterizing enzymes in various metabolic pathways, in organisms ranging from bacteria to plants to humans. In addition to crystallography, we use methods such as enzyme kinetics, small angle X-ray scattering, and hydrogen deuterium exchange, as well as various bioinformatic and computational approaches.