Education

Research Area

Combinatorial biology applied to cancer detection and therapy.

Research Description

Our laboratory is interested in discerning the role of carbohydrate and protein-protein interactions in cancer. Work focuses on applying novel combinatorial phage display approaches and structural biochemistry to characterize these interactions. Combinatorial chemistry and phage display allows for the rapid selection from many millions of sequences to find peptide molecules that bind almost any given target such as cancer antigens. We have isolated peptides that are being utilized to specifically modulate cancer cell adhesion events. Once radiolabeled, the peptides will prove valuable as selective cancer imaging and therapeutic agents.

Notable Honors and Service

• Co-director, NIH/NEI Center for Single Photon-Emitting Cancer-Imaging Agents
• Veterans Administration Research Merit Award (1994-96; 1998-2020)

Selected Publications

Deutscher S. (2019). Phage Display to Detect and Identify Autoantibodies in Disease. N Engl J Med 381(1): 89-91. doi: 10.1056/NEJMcibr1903249. [PubMed]

Peng Y, Prater AR, Deutscher SL. (2017). Targeting aggressive prostate cancer-associated CD44v6 using phage display selected peptides. Oncotarget. 8(49):86747-86768. doi: 10.18632/oncotarget.21421. eCollection 2017 Oct 17. [PubMed]

Newton-Northup J, Deutscher SL. (2017). Characterization of In Vivo Selected Bacteriophage for the Development of Novel Tumor-Targeting Agents with Specific Pharmacokinetics and Imaging Applications. Methods Mol Biol. 1572:445-465. doi: 10.1007/978-1-4939-6911-1_29. [PubMed]

Northup JR, Deutscher SL. (2016). Cytotoxic Tumor-Targeting Peptides From In Vivo Phage Display. Comb Chem High Throughput Screen. 19(5):370-7. [PubMed]

Larimer BM, Quinn JM, Kramer K, Komissarov A, Deutscher SL. (2015). Multiple Bacteriophage Selection Strategies for Improved Affinity of a Peptide Targeting ERBB2. Int J Pept Res Ther. 21(4):383-392. [PubMed]

Larimer BM, Deutscher SL. (2014). Identification of a Peptide from In vivo Bacteriophage Display with Homology to EGFL6: A Candidate Tumor Vasculature Ligand in Breast Cancer. J Mol Biomark Diagn. 5(3). [PubMed]

Larimer BM, Deutscher SL. (2014). Development of a peptide by phage display for SPECT imaging of resistance-susceptible breast cancer. Am J Nucl Med Mol Imaging. 4(5):435-47. eCollection 2014. [PubMed]

Deutscher SL. (2010). Phage display in molecular imaging and diagnosis of cancer. Chem Rev. 110(5):3196-211. doi: 10.1021/cr900317f. Review. [PubMed]