Animal Reproductive Biology Group

Julia A. Taylor

Research Assistant Professor

Phone: (573)882-2482
E-mail: TaylorJA@missouri.edu
Address: 6 Lefevre Hall

Education

B.A., University of Keele-United Kingdom
Ph.D., University of Keele-United Kingdom

Research Focus

Prostate development
Steroid hormone action
Endocrine disruption

Research Description

Taylor's research interests center on the effects of the early endocrine environment on development of the reproductive system, and on the actions of steroid hormones and their receptors.

Taylor is using the fetal prostate as a model system to study mechanisms of estrogen action during early development. Early prostate development and differentiation depend on the presence of androgens, but exposure to even very low levels of estrogenic chemicals during fetal life can alter differentiation of the urogenital sinus, resulting in a permanent increase in prostate size, as well as glandular hyperplasia and an increase in prostatic androgen receptors.

Taylor's main focus is on the mechanisms by which natural estrogens influence normal prostate growth and development. However, environmental chemicals that mimic endogenous hormones can also impact prostate development, and Taylor also uses this model system to examine consequences of endocrine disruption.

Recent Publications

Pamidimukkala J, Taylor JA, Welshons WV, Lubahn DB, Hay M.
Estrogen modulation of baroreflex function in conscious mice. Am J Physiol Regul Integr Comp Physiol. 2003 Apr;284(4):R983-9. Epub 2003 Jan 9. PMID: 12521927
Cooke PS, Heine PA, Taylor JA, Lubahn DB.
The role of estrogen and estrogen receptor-alpha in male adipose tissue. Mol Cell Endocrinol. 2001 Jun 10;178(1-2):147-54. Review. PMID: 11403904
Kurita T, Lee K, Saunders PT, Cooke PS, Taylor JA, Lubahn DB, Zhao C, Makela S, Gustafsson JA, Dahiya R, Cunha GR.
Regulation of progesterone receptors and decidualization in uterine stroma of the estrogen receptor-alpha knockout mouse. Biol Reprod. 2001 Jan;64(1):272-83. PMID: 11133684
Heine PA, Taylor JA, Iwamoto GA, Lubahn DB, Cooke PS.
Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12729-34. PMID: 11070086
Cunha GR, Young P, Hom YK, Cooke PS, Taylor JA, Lubahn DB.
Elucidation of a role for stromal steroid hormone receptors in mammary gland growth and development using tissue recombinants. J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):393-402. Review. PMID: 10935027
Kurita T, Lee KJ, Cooke PS, Taylor JA, Lubahn DB, Cunha GR.
Paracrine regulation of epithelial progesterone receptor by estradiol in the mouse female reproductive tract. Biol Reprod. 2000 Apr;62(4):821-30. Erratum in: Biol Reprod 2000 Jul;63(1):354. PMID: 10727249
Ghosh D, Taylor JA, Green JA, Lubahn DB.
Methoxychlor stimulates estrogen-responsive messenger ribonucleic acids in mouse uterus through a non-estrogen receptor (non-ER) alpha and non-ER beta mechanism. Endocrinology. 1999 Aug;140(8):3526-33. PMID: 10433208
Taylor JA, Lewis KJ, Lubahn DB.
Estrogen receptor mutations. Mol Cell Endocrinol. 1998 Oct 25;145(1-2):61-6. Review. PMID: 9922100
Buchanan DL, Setiawan T, Lubahn DB, Taylor JA, Kurita T, Cunha GR, Cooke PS.
Tissue compartment-specific estrogen receptor-alpha participation in the mouse uterine epithelial secretory response. Endocrinology. 1999 Jan;140(1):484-91. PMID: 9886861
Buchanan DL, Kurita T, Taylor JA, Lubahn DB, Cunha GR, Cooke PS.
Role of stromal and epithelial estrogen receptors in vaginal epithelial proliferation, stratification, and cornification. Endocrinology. 1998 Oct;139(10):4345-52. PMID: 9751518
A complete list of publications for JA Taylor in PubMed