Animal Reproductive Biology Group

Michael F. Smith

Professor
Animal Sciences

Phone: 573-882-8239
E-mail: SmithMF@missouri.edu
Address: 160 Animal Science Research Center

Education

B.S., Colorado State University
M.S., Texas A&M University
Ph.D., Texas A&M University

Research Focus

Ovarian function
Ovarian tissue remodeling

Research Description

Smith's primary research goal is to elucidate the physiological mechanisms regulating ovarian function.

Specifically, he has focused on the regulation of ovarian extracellular matrix (ECM) remodeling. Matrix metalloproteinases (MMPs) are enzymes that cleave specific components of the ECM and are specifically inhibited by a family of inhibitors known as tissue inhibitors of metalloproteinases (TIMPs). Smith's research is aimed at determining the role of MMPs/TIMPs in follicular maturation and the physiological role of TIMP-1 in luteal function.

In addition, Smith is studying luteal progesterone receptors. There is evidence indicating that progesterone may have direct effects on ovarian cells. Smith's research goals are to quantitate progesterone receptor mRNA expression and receptor protein expression in ovine luteal tissue and dispersed luteal cells, to determine whether the cells containing progesterone receptors in ovine corpora luteal in situ, are steroidogenic, and to determine the effect of a progesterone agonist and antagonist on progesterone secretion by luteinizing granulosal cells and dispersed luteal cells.

Smith is also studying the regulation of bovine follicular waves. Studies were designed to characterize changes in the expression of gonadotropin receptors, steroidogenic enzymes, and steroidogenic acute regulatory protein at different stages of the first follicular wave.

Recent Publications

Lamberson WR, Smith MF.
Encouraging science reading beyond the curriculum. J Anim Sci. 2005 Aug;83(8):1972-5. PMID: 16024719
Mao J, Wu GM, Prather RS, Smith MF, Cantley T, Rieke A, Didion BA, Day BN.
Effect of methyl-beta-cyclodextrin treatment of pig spermatozoa on in vitro fertilization and embryo development in the absence or presence of caffeine. Theriogenology. 2005 May 23; [Epub ahead of print] PMID: 15919108
Perry GA, Smith MF, Lucy MC, Green JA, Parks TE, MacNeil MD, Roberts AJ, Geary TW.
Relationship between follicle size at insemination and pregnancy success. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5268-73. Epub 2005 Mar 28. PMID: 15795381
Perry GA, Welshons WV, Bott RC, Smith MF.
Basis of melengestrol acetate action as a progestin. Domest Anim Endocrinol. 2005 Feb;28(2):147-61. PMID: 15713363
Smith MF, Gutierrez CG, Ricke WA, Armstrong DG, Webb R.
Production of matrix metalloproteinases by cultured bovine theca and granulosa cells. Reproduction. 2005 Jan;129(1):75-87. PMID: 15615900
Bader JF, Kojima FN, Schafer DJ, Stegner JE, Ellersieck MR, Smith MF, Patterson DJ.
A comparison of progestin-based protocols to synchronize ovulation and facilitate fixed-time artificial insemination in postpartum beef cows. J Anim Sci. 2005 Jan;83(1):136-43. PMID: 15583053
Wood-Follis SL, Kojima FN, Lucy MC, Smith MF, Patterson DJ.
Estrus synchronization in beef heifers with progestin-based protocols. I. Differences in response based on pubertal status at the initiation of treatment. Theriogenology. 2004 Nov;62(8):1518-28. PMID: 15451259
Mao J, Smith MF, Rucker EB, Wu GM, McCauley TC, Cantley TC, Prather RS, Didion BA, Day BN.
Effect of epidermal growth factor and insulin-like growth factor I on porcine preantral follicular growth, antrum formation, and stimulation of granulosal cell proliferation and suppression of apoptosis in vitro. J Anim Sci. 2004 Jul;82(7):1967-75. PMID: 15309943
Hampton JH, Bader JF, Lamberson WR, Smith MF, Youngquist RS, Garverick HA.
Gonadotropin requirements for dominant follicle selection in GnRH agonist-treated cows. Reproduction. 2004 Jun;127(6):695-703. PMID: 15175506
Hampton JH, Manikkam M, Lubahn DB, Smith MF, Garverick HA.
Androgen receptor mRNA expression in the bovine ovary. Domest Anim Endocrinol. 2004 Jul;27(1):81-8. PMID: 15158536
A complete list of publications for MF Smith in PubMed