Animal Reproductive Biology Group

Heide Schatten

Associate Professor
Veterinary Pathobiology

Phone: 573-882-2396
E-mail: SchattenH@missouri.edu
Address: W123 Veterinary Medical Building

Education

B.S., University of Heidelberg
M.S., University of Heidelberg
Ph.D., University of Heidelberg
Postdoc, University of California

Research Focus

Cytoskeletal organization during reproduction
Fertilization, cell division and embryo development

Research Description

Schatten's research focuses on cytoskeletal structure and function in cells during reproduction, during aging, and in cancers of the reproductive systems including breast and prostate cancers.

The goal of this research is to investigate regulation of normal cytoskeletal function and abnormalities that lead to dysfunction and/or disease.

Schatten is most interested in microtubules and their organizing centers (centrosomes), which play a crucial role in the union of the maternal and paternal genome during fertilization and in the separation of the united genomes during cell division and cell differentiation.

Schatten is also studying the effects of microgravity on calcium metabolism and cytoskeletal organization during fertilization in the space environment. This research is funded by NASA.

Schatten's studies on aging and reproductive cancers are focused on cell-cycle specific phosphorylation of centrosomes. She has started to investigate the cascade of signal transduction events that will trigger centrosome protein phosphorylation.

Recent Publications

Cao YK, Zhong ZS, Chen DY, Zhang GX, Schatten H, Sun QY.
Cell cycle-dependent localization and possible roles of the small GTPase Ran in mouse oocyte maturation, fertilization and early cleavage. Reproduction. 2005 Oct;130(4):431-40. PMID: 16183861
Zhang YL, Chen T, Jiang Y, Zhong ZS, Liu SZ, Hou Y, Schatten H, Chen DY, Sun QY.
Active demethylation of individual genes in intracytoplasmic sperm injection rabbit embryos. Mol Reprod Dev. 2005 Dec;72(4):530-3. PMID: 16161163
Schatten H, Prather RS, Sun QY.
The significance of mitochondria for embryo development in cloned farm animals. Mitochondrion. 2005 Oct;5(5):303-21. PMID: 16150655
Sun QY, Schatten H.
Role of NuMA in vertebrate cells: review of an intriguing multifunctional protein. Front Biosci. 2006 Jan 1;11:1137-46. PMID: 16146802
Liang CG, Huo LJ, Zhong ZS, Chen DY, Schatten H, Sun QY.
Cyclic adenosine 3',5'-monophosphate-dependent activation of mitogen-activated protein kinase in cumulus cells is essential for germinal vesicle breakdown of porcine cumulus-enclosed oocytes. Endocrinology. 2005 Oct;146(10):4437-44. Epub 2005 Jul 7. PMID: 16002524
Chen T, Jiang Y, Zhang YL, Liu JH, Hou Y, Schatten H, Chen DY, Sun QY.
DNA hypomethylation of individual sequences in aborted cloned bovine fetuses. Front Biosci. 2005 Sep 1;10:3002-8. PMID: 15970554
Zhong ZS, Zhang G, Meng XQ, Zhang YL, Chen DY, Schatten H, Sun QY.
Function of donor cell centrosome in intraspecies and interspecies nuclear transfer embryos. Exp Cell Res. 2005 May 15;306(1):35-46. Epub 2005 Mar 17. PMID: 15878330
Zheng ZY, Li QZ, Chen DY, Schatten H, Sun QY.
Translocation of phospho-protein kinase Cs implies their roles in meiotic-spindle organization, polar-body emission and nuclear activity in mouse eggs. Reproduction. 2005 Feb;129(2):229-34. PMID: 15695617
Chen T, Zhang YL, Jiang Y, Liu SZ, Schatten H, Chen DY, Sun QY.
The DNA methylation events in normal and cloned rabbit embryos. FEBS Lett. 2004 Dec 3;578(1-2):69-72. PMID: 15581618
Schatten H, Ris H.
Three-dimensional imaging of Toxoplasma gondii-host cell interactions within the parasitophorous vacuole. Microsc Microanal. 2004 Oct;10(5):580-5. PMID: 15525432
A complete list of publications for H Schatten in PubMed