Animal Reproductive Biology Group

Cheryl Rosenfeld

Assistant Professor
Veterinary Biomedical Sciences

Phone: 573-882-6798
E-mail: RosenfeldC@missouri.edu
Address: 440f Life Sciences Center

Education

B.S., University of Illinois
D.V.M., University of Illinois
Ph.D., University of Missouri

Research Focus

Human endometrial cancers
Maternal diet and offspring sex ratio

Research Description

Rosenfeld is interested in studying the putative therapeutic effects of type I IFN on treating human endometrial cancers.

Past studies have suggested that type I IFN, such as IFN-a and IFN-b, in combination with anti-estrogens might hold greater promise for treating estrogen-responsive tumors.

Rosenfeld is examining the effects that IFN-a and raloxifene have on various human endometrial cancer cells. In addition, she is examining the effects that type I IFN have on normal uterine estrogen receptor expression.

Further studies will examine the effects of IFN on estrogen-responsive genes using microarray technology.

Rosenfeld's second area of interest involves studying the effects that maternal diet has on offspring sex ratio.

There is some evidence to suggest that in several mammals, mothers on a restricted calorie intake produce daughters more frequently than sons. In contrast, energy-rich diets may favor sons.

The hypothesis is that diet, either directly or indirectly, influences the nutrient conditions within the reproductive tract of an early pregnant female. An ability to manipulate sex of offspring through diet has potentially important application in the livestock industry.

Recent Publications

Rosenfeld CS, Roberts RM.
Maternal diet and other factors affecting offspring sex ratio: a review. Biol Reprod. 2004 Oct;71(4):1063-70. Epub 2004 Jun 30. Review. PMID: 15229140
Roberts RM, Ezashi T, Rosenfeld CS, Ealy AD, Kubisch HM.
Evolution of the interferon tau genes and their promoters, and maternal-trophoblast interactions in control of their expression. Reprod Suppl. 2003;61:239-51. Review. PMID: 14635939
Rosenfeld CS, Grimm KM, Livingston KA, Brokman AM, Lamberson WE, Roberts RM.
Striking variation in the sex ratio of pups born to mice according to whether maternal diet is high in fat or carbohydrate. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4628-32. Epub 2003 Apr 2. PMID: 12672968
Rosenfeld CS, Han CS, Alexenko AP, Spencer TE, Roberts RM.
Expression of interferon receptor subunits, IFNAR1 and IFNAR2, in the ovine uterus. Biol Reprod. 2002 Sep;67(3):847-53. PMID: 12193393
Chen X, Rosenfeld CS, Roberts RM, Green JA.
An aspartic proteinase expressed in the yolk sac and neonatal stomach of the mouse. Biol Reprod. 2001 Oct;65(4):1092-101. PMID: 11566730
Rosenfeld CS, Wagner JS, Roberts RM, Lubahn DB.
Intraovarian actions of oestrogen. Reproduction. 2001 Aug;122(2):215-26. Review. PMID: 11467972
Rosenfeld CS, Roberts RM, Lubahn DB.
Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus. Mol Reprod Dev. 2001 Jul;59(3):336-46. Review. PMID: 11424220
Rosenfeld CS, Cooke PS, Welsh TH Jr, Simmer G, Hufford MG, Gustafsson JA, Hess RA, Lubahn DB.
The differential fate of mesonephric tubular-derived efferent ductules in estrogen receptor-alpha knockout versus wild-type female mice. Endocrinology. 2000 Oct;141(10):3792-8. PMID: 11014235
Yellayi S, Teuscher C, Woods JA, Welsh TH Jr, Tung KS, Nakai M, Rosenfeld CS, Lubahn DB, Cooke PS.
Normal development of thymus in male and female mice requires estrogen/estrogen receptor-alpha signaling pathway. Endocrine. 2000 Jun;12(3):207-13. PMID: 10963039
Rosenfeld CS, Murray AA, Simmer G, Hufford MG, Smith MF, Spears N, Lubahn DB.
Gonadotropin induction of ovulation and corpus luteum formation in young estrogen receptor-alpha knockout mice. Biol Reprod. 2000 Mar;62(3):599-605. PMID: 10684800
A complete list of publications for CS Rosenfeld in PubMed