Animal Reproductive Biology Group

Susan Nagel

Assistant Professor
Ob, Gyn and Women's Health

Phone: 573-884-3028
E-mail: NagelS@health.missouri.edu
Address: M659 Medical Science Building

Education

B.S., Hendrix College
Ph.D., University of Missouri
Postdoc, Duke University

Research Focus

Fetal programming of adult gene expression by endogenous and xenobiotic (environmental) estrogens
Fetal programming of endometriosis related gene expression
Tissue specific expression of estrogen receptor interacting proteins
Estrogen receptor conformation to predict in vivo biological activity of xenobiotic estrogens

Recent Publications

vom Saal FS, Nagel SC, Timms BG, Welshons WV.
Implications for human health of the extensive bisphenol A literature showing adverse effects at low doses: a response to attempts to mislead the public. Toxicology. 2005 Sep 1;212(2-3):244-52, author reply 253-4. No abstract available. PMID: 15975703
vom Saal FS, Richter CA, Ruhlen RR, Nagel SC, Timms BG, Welshons WV.
The importance of appropriate controls, animal feed, and animal models in interpreting results from low-dose studies of bisphenol A. Birth Defects Res A Clin Mol Teratol. 2005 Mar;73(3):140-5. PMID: 15751043
Jansen MS, Nagel SC, Miranda PJ, Lobenhofer EK, Afshari CA, McDonnell DP.
Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204. Epub 2004 Apr 21. PMID: 15103026
Sathya G, Jansen MS, Nagel SC, Cook CE, McDonnell DP.
Identification and characterization of novel estrogen receptor-beta-sparing antiprogestins. Endocrinology. 2002 Aug;143(8):3071-82. PMID: 12130573
Nagel SC, Hagelbarger JL, McDonnell DP.
Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. Endocrinology. 2001 Nov;142(11):4721-8. PMID: 11606437
Wijayaratne AL, Nagel SC, Paige LA, Christensen DJ, Norris JD, Fowlkes DM, McDonnell DP.
Comparative analyses of mechanistic differences among antiestrogens. Endocrinology. 1999 Dec;140(12):5828-40. PMID: 10579349
Nagel SC, vom Saal FS, Welshons WV.
Developmental effects of estrogenic chemicals are predicted by an in vitro assay incorporating modification of cell uptake by serum. J Steroid Biochem Mol Biol. 1999 Apr-Jun;69(1-6):343-57. Review. PMID: 10419012
Welshons WV, Nagel SC, Thayer KA, Judy BM, vom Saal FS.
Low-dose bioactivity of xenoestrogens in animals: fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice. Toxicol Ind Health. 1999 Jan-Mar;15(1-2):12-25. PMID: 10188188
Nagel SC, vom Saal FS, Welshons WV.
The effective free fraction of estradiol and xenoestrogens in human serum measured by whole cell uptake assays: physiology of delivery modifies estrogenic activity. Proc Soc Exp Biol Med. 1998 Mar;217(3):300-9. PMID: 9492339
vom Saal FS, Cooke PS, Buchanan DL, Palanza P, Thayer KA, Nagel SC, Parmigiani S, Welshons WV.
A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicol Ind Health. 1998 Jan-Apr;14(1-2):239-60. PMID: 9460178
A complete list of publications for SC Nagel in PubMed