Animal Reproductive Biology Group

Jonathan Green

Assistant Professor
Animal Sciences

Phone: 573-884-1697
Fax: 573-882-6827
E-mail: GreenJO@missouri.edu
Address: 163 Animal Science Research Center

Education

B.S., Idaho State University
Ph.D., University of Missouri
Postdoc, University of Missouri

Research Focus

Placenta-uterine interface

Research Description

Green's primary research goal is the examination of the interactions that take place at the placenta-uterine interface with a particular emphasis on the molecular events involved in trophoblast and endometrium differentiation and gene expression.

Green's research centers on pregnancy-associated glycoproteins (PAGs) and Trophoblast Kunitz Domain Proteins (TKDPs). The PAGs comprise a large gene family expressed by trophoblasts of species within the Artiodactyla order (ruminants, camels and pigs). These proteins are present in the maternal circulation and serve as useful markers of pregnancy.

Current studies are centered on understanding PAG function in ruminant reproduction. The TKDPs, like the PAGs, are secretory products of trophoblast. They belong to the Kunitz family of serine proteinase inhibitors. Most are expressed throughout gestation, although their maximal expression is around the time of implantation. Recombinant forms of these proteins have been generated to examine the proteinase inhibitory activity of the Kunitz domains and to identify proteins with which they can associate in vivo and in-vitro.

In addition, Green is interested in expression profiling of the conceptus and endometrium during early pregnancy. The goal of this work is to examine global changes in gene expression due to developmental changes and hormone/drug treatments.

Recent Publications

Perry GA, Smith MF, Lucy MC, Green JA, Parks TE, MacNeil MD, Roberts AJ, Geary TW.
Relationship between follicle size at insemination and pregnancy success. Proc Natl Acad Sci U S A. 2005 Apr 5;102(14):5268-73. Epub 2005 Mar 28. PMID: 15795381
Green JA, Parks TE, Avalle MP, Telugu BP, McLain AL, Peterson AJ, McMillan W, Mathialagan N, Hook RR, Xie S, Roberts RM.
The establishment of an ELISA for the detection of pregnancy-associated glycoproteins (PAGs) in the serum of pregnant cows and heifers. Theriogenology. 2005 Mar 15;63(5):1481-503. PMID: 15725453
Whitworth KM, Agca C, Kim JG, Patel RV, Springer GK, Bivens NJ, Forrester LJ, Mathialagan N, Green JA, Prather RS.
Transcriptional profiling of pig embryogenesis by using a 15-K member unigene set specific for pig reproductive tissues and embryos. Biol Reprod. 2005 Jun;72(6):1437-51. Epub 2005 Feb 9. PMID: 15703372
Wooding FB, Roberts RM, Green JA.
Light and electron microscope immunocytochemical studies of the distribution of pregnancy associated glycoproteins (PAGs) throughout pregnancy in the cow: possible functional implications. Placenta. 2005 Nov;26(10):807-27. Epub 2004 Dec 23. PMID: 16226131
Prather RS, Sutovsky P, Green JA.
Nuclear remodeling and reprogramming in transgenic pig production. Exp Biol Med (Maywood). 2004 Dec;229(11):1120-6. Review. PMID: 15564438
Green JA.
Defining the function of a prolactin gene family member. Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16397-8. Epub 2004 Nov 16. No abstract available. PMID: 15546986
Hughes AL, Green JA, Piontkivska H, Roberts RM.
Aspartic proteinase phylogeny and the origin of pregnancy-associated glycoproteins. Mol Biol Evol. 2003 Nov;20(11):1940-5. Epub 2003 Aug 29. PMID: 12949149
A complete list of publications for JA Green in PubMed