Animal Reproductive Biology Group

Eric Antoniou

Assistant Professor
Animal Sciences

Phone: 573-884-8769
Fax: 573-882-6827
E-mail: AntoniouE@missouri.edu
Address: S140 Animal Science Research Center

Education

B.S., University of Bordeaux I
B.S., University of Bordeaux II
Ph.D., University of Limoges

Research Focus

Gene expression
Ovarian follicular development
Heat stress and homeostasis

Research Description

Antoniou's major research goal is to understand changes in gene expression during follicular development. Lack of, or abnormal, ovarian follicular development is a major factor associated with decreased fertility in mammalian species.

Continued development of ovarian follicles towards ovulation likely involves the temporal and spatial expression of numerous genes that regulate cellular proliferation, cellular differentiation, tissue remodeling, angiogenesis and steroidogenesis.

Antoniou is using DNA microarrays and proteomics to understand changes in gene expression associated with follicular development in cattle.

Another research goal of Antoniou's is to identify genes that change with thermal status from thermoneutral to heat stress conditions.

Summer heat stress results annually in billions of dollars of lost animal productivity and impaired animal health in the United States. Heat stress occurs in cattle due to a combination of environmental factors that result in drastic changes in behavior and physiology.

Although these effects are well documented, the resulting changes in cellular functions and gene regulation are poorly understood. Antoniou is using high throughput DNA microarrays to identify gene expression changes associated with heat stress in liver and muscle of mice.

Recent Publications

Liu Z, Womack JE, Antoniou E.
A high-resolution comparative RH map of the telomeric end of bovine chromosome 2 with human chromosomes 1 and 2. Cytogenet Genome Res. 2003;103(1-2):89-93. PMID: 15004470
Liu Z, Hansen M, Womack JE, Antoniou E.
A comparative map of interstitial bovine chromosome 5 with human chromosomes 12 and 22. Cytogenet Genome Res. 2003;101(2):147-54. PMID: 14610356
Antoniou E, Gallagher D Jr, Taylor J, Davis S, Womack J, Grosz M.
A comparative map of bovine chromosome 25 with human chromosomes 7 and 16. Cytogenet Genome Res. 2002;97(1-2):128-32. PMID: 12438751
Antoniou E, Gallagher D.
Chromosomal assignment of the bovine ubiquitin-conjugating enzyme E2I (UBE2I ) gene to BTA6q34 defines a new fragment of conserved synteny with human chromosome 16. Anim Genet. 2002 Oct;33(5):388-9. No abstract available.
Antoniou E, Grosz M.
PCR based detection of bovine myostatin Q204X mutation. Anim Genet. 1999 Jun;30(3):231-2. No abstract available. PMID: 10442997
Antoniou E, Womack JE, Grosz MD.
Synteny mapping of five human chromosome 7 genes on bovine chromosomes 4 and 21. Cytogenet Cell Genet. 1999;84(1-2):121-4. PMID: 10343125
David G, Abbas N, Stevanin G, Durr A, Yvert G, Cancel G, Weber C, Imbert G, Saudou F, Antoniou E, Drabkin H, Gemmill R, Giunti P, Benomar A, Wood N, Ruberg M, Agid Y, Mandel JL, Brice A.
Cloning of the SCA7 gene reveals a highly unstable CAG repeat expansion. Nat Genet. 1997 Sep;17(1):65-70. PMID: 9288099
A complete list of publications for E Antoniou in PubMed